I've killed more deer than I can count over the last 20+ years with a 22-250 but on the other end of the spectrum I also have a 7mm mag. It's down to the shooter and how comfortable they are behind the gun and if they are willing to wait for the right kill shot required for the caliber they selected. I shoot all my deer in the neck or head, especially when shooting the 22-250. That means I do have to let more deer walk than I would if I were shooting a larger caliber gun and going for vitals but that's part of the challenge for me and I'm willing to accept that.
I totally agree.
If you are going to deer hunt with a varmint rifle, you need to be proficient enough to shoot them in the head/neck.
I still shoot doe deer in the head with my 300 wm. I'll shoot a nice buck a couple of inches behind the shoulder, and have yet to have any to them take another step.
But Bear44 says you are stupid if you feel confident enough in your marksmanship to shoot a deer in the head and that he doesn't waste any meat by shooting all his deer in the heart, without going in or out either shoulder.
Those that can't shoot, try to justify shooting center mass with being ethical. SMH