Dillon, nuff said
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Dillon is the easiest to change calibers but they changes cost more. Dillon uses caliber specific parts for the caliber changes whereas Hornady is more adjustable. Adjustable = Finicky. If you are cost sensitive and don't mind spending a bit more time adjusting the LNL AP would be a better choice. If you want caliber changes to take minutes and don't mind spending the money, A dillon 650 with a tool head for each caliber would be the choice. I have both and will eventually get rid of one.
Bet it will not be the "BIG BLUE DILLON."
Ah that’s the way it leaning. I use the Hornady more because it doesn’t have the case feed so less to change. I will sometimes load a run of 300blk then some pistol in the same sitting. The 650 isn’t really conducive to that unless you spend a few hundred per caliber. You could practically have 3 lnl aps for less than a 650 with two complete tool heads and all the conversion parts.