Funny. I have a dislike for 300 and .270. There's no reason why really. I just have never really cared for them.
I will say, however, that I have seen more actual reports of hunters having issues with 300 (both sub and super). Now of course that could be for a variety of reasons, but it does seem to be a common theme.
My buddy loads the 125grn NBT load that I have for deer. He's been killing deer and hogs with it for years down in South Georgia, using a 16" carbine. He likes it a lot.