Shhh! Let him take the bait a little before confusing OP with the SAMMI vs SPCII "talk". Lolfor sure it's comparable to any other premium hunting round. Just a lot more expensive to blast off a 30 round magazine when you go out with friends. which you will want to do if you line up a bunch of pumpkins and other "expendables". but if you reload and save your brass, that's where it really shines. plus you can load to whatever spec you have in your rifle (there were some different specs for chambers over the years) so you can take advantage of the velocity if you want.
Hand loading will definitely wring out all the performance allowed in the improved SPCII chamber (most new rifles and barrels made now). But to be honest, the multitude of different factory loadings that ARE compatible with the SAMMI chambers will work plenty well enough for the typical hunter whether the quarry is hog, deer, coyote, HD, paper, or the ever-elusive pumpkin.