Friendly contrarian here . . . I've fired a military .45 and loved it. It's not my favorite, and I like .380 or 9 mm for EDC, but if I had to make a choice in a bad situation that's what I'd grab.
i keep the Sig 40 "in house" because of the mag capacity & I put a Crimson Trace laser on it. I figure most home invasions will likely be at night. My actual preference is a 357 mag because of the versatility of the caliber from low velocity 39SP loads to full house 357s. For some reason I am more comfortable & accurate with a revolver, so I carry a S&W 686. I have never had an aggressive encounter & hope I never do, but if it happens, an accurate placement by something with a big punch may save the day.
Be aware.......be sasfe