People do the Pan American all the time on motorcycles, camper vans, bicycles etc.. There is about a 66 mile interruption to the route that goes thru the Darien Gap...Your gonna want to put your rig on a ferry to get between Panama and Columbia
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I remember that.Didn't Top Gear try this? I seem to remember that they had to bail out at the end because of hard feelings over the Falklands war in Argentina?