I do, but there are no blind spots in the tree stand like there are in a ground blind. I only keep two of the four Windows slightly open so I don't get back-lit...too easy for them to sneak up from behind.
I had a cub climb the tree next to the one I was in to get a better look at what I was...
I have a ground blind and a tree stand in that area for use at different times and wind conditions but think I'll be spending more time in the tree this year