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A 22 in the pocket is better than a 45 in the truck.
Many of intruders have been stopped an killed by kids being hone alone armed only with a 22 rifle.
true story!
I've seen plenty of dead people shot by .22s, my mkiii 22/45 is loaded and in a room of my house, if its the closest gun when I need it I have no problem usinging it till I get to a larger gun.
So you aren't even concerned with size in this situation and STILL chose to use a 22. That is such a bad idea I can't even express it. You say, "I have no problem usinging it till I get to a larger gun." I absolutely guaranty that you are dramatically reducing your chances of getting to that larger gun by using a 22 for self defense.