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I've looked and they are the most energy out of any readily available .22lr cartridge that I could find.Aguila 22 Interceptor Is the round you want because penetration is the goal In big animals as someone already wrote.
40 Grain solid copper plated lead Rated at 1470 FPS. That is only a couple hundred FPS slower than 22 Mag if the velocity is accurate.
I bought 2 bricks but not have had a chance to test it.
They are loaded in my home coyote getter at the moment. I suspect, OP's "clients" aren't going to burning through thousands of rounds practicing anyway so the added cost shouldn't be a big issue.

