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Never thought I would ask a 22LR ammo question like this

Aguila 22 Interceptor Is the round you want because penetration is the goal In big animals as someone already wrote.
40 Grain solid copper plated lead Rated at 1470 FPS. That is only a couple hundred FPS slower than 22 Mag if the velocity is accurate.
I bought 2 bricks but not have had a chance to test it.
I've looked and they are the most energy out of any readily available .22lr cartridge that I could find.
They are loaded in my home coyote getter at the moment. I suspect, OP's "clients" aren't going to burning through thousands of rounds practicing anyway so the added cost shouldn't be a big issue.
 
Aguila has a dynamite little round...cant remember the name of it,but easy enough to google.It shoots a 30 grain hollowpoint at a blistering 1700fps.Shot good outa the buckmark.Havnt tried out of a rifle yet,but wouldnt matter at home defense ranges.This beats the pants off the stinger velocity wise.I believe it to be the fastest 22LR round you can get at the present@ 1700 vs 1640 for the stinger.Bullseye in Lawrenceville has them @5.99 a box of 50.
 
Aguila has a dynamite little round...cant remember the name of it,but easy enough to google.It shoots a 30 grain hollowpoint at a blistering 1700fps.Shot good outa the buckmark.Havnt tried out of a rifle yet,but wouldnt matter at home defense ranges.This beats the pants off the stinger velocity wise.I believe it to be the fastest 22LR round you can get at the present@ 1700 vs 1640 for the stinger.Bullseye in Lawrenceville has them @5.99 a box of 50.
It's their "SuperMaximum". Same energy as the Interceptor.
 
The direct answer to the OP's question about using only one brand and one specific type of ammunition for both plinking and protection,
in .22 LR, would be CCI Mini mags.
They're not the best quality, but on the other hand they are not outrageously expensive like Stingers are! Ammo used for plinking cannot be ridiculously high priced --that defeats the purpose of plinking and having fun.

Of course you'd need to test those rounds, and whatever magazines you intend to use, first before you trust your life on it.

When I first moved to New York it took one year to get my concealed carry permit. During that one year my "vehicle defense gun" away from the home was a Ruger model 10/22 cut down to have a 16 inch barrel and a shorter stock with a 12 inch length of pull. The ammo with CCI Mini mag hollow points, and the magazine I carried in it was the factory 10 round rotary magazine (to keep the gun's profile slim and handy, and snag-free).
But the spare mags I kept handy were Ram-line 25 rounders (which worked very well in my gun).
 
My father had a 22 revolver (among others) for protection.
He was willing to have two types of ammo-
1--super high-quality ammo with reliable primers for defense,
and
2--cheap ammo for plinking and casual target shooting.

I think the ammo for defense was Lapua or Eley or RWS brand. It was high velocity match (solid point). I think it was made for rimfire metallic silhouette competition so it would have the energy to knock down metal targets at a distance.
But this stuff is very expensive.

For the range, we generally used CCI Blazer, Winchester Wildcat, or Federal.
We avoided Remington like the plague because it was so unreliable and inconsistent in both bullet sizing and velocity.
 
No need for Stingers. Use CCI Mini-Mag Segmented HP's. They are not as fast as Stingers, but they are a 40 grain segmented projectile and will create three wound channels instead of only one. They have Stinger-type Segmented HP's as well, but they are only 32 grains. I'd go with the heavier bullet since you won't be shooting long distances anyways. At 50 yards, they are still going around 1,100 fps.

With a .22 the key is to get someone to stop coming at you and/or retreat and leave. That's why the Isreali military uses them to shoot people in the legs and thighs. It stops their approach and allows a follow-up shot to the head if necessary, which is rather painful I would think.

https://www.cci-ammunition.com/rimfire/cci/mini-mag_segmented_hp/6-36CC.html

Oh, and the 15-round Ruger magazines (BX-15) are 100% reliable in my experience. Five more rounds and a lot easier to load and unload than the BX-1.
 
I’ve had several 10/22’s over the years and the Stingers didn’t give me consistent groups. They were nice and hot but all over the target beyond 50 yards.

Now the 40 grain Federal Gold Medal works great in all of them. Slayed many many squirrels and a hog on a WMA squirrel hunt a few years back.
So, if you aim for the nose and hit the eyeball, that's a problem? I think it would still cause the so-called "intruder" to re-think his current choice of invading your home.
 
It's their "SuperMaximum". Same energy as the Interceptor.
Thank you...thats the one.If I was reduced to only a pistol in 22 for protection,thats the one Id pick.Plenty accurate for inside the same room eyeball shots.A semi-auto rifle,Id choose what held the best balance of these criteria in the order of reliability,accuracy,velocity,weight/design of bullet,then cost.Thanks to the author of the original post,as this has been interesting to ponder.
 
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