Yes, 45 Colt and 454 would be like 38/ 357. As long as it doesn't blow up in your face you probably have a real gemso itll shoot 45 colt? and that will be less detramental so to say on the gun? ive already taken a deer with it, using 454 casull 300gr hallows so even if it just sits on the wall, or in the case im pretty ok with that. its a cool gun for sure