What a lot of people miss when comparing rounds is actual cross sectional area. OK, maybe there's a temporary cavity, maybe not. There is certainly a permanent wound channel, and the larger that channel is, the more likely it is to hit something that quickly incapacitates the bad guy. So what comes into play is exactly how much meat is pushed out of place, or the size of the cylinder of destruction.
It isn't the caliber diameter that you compare, it's the area. To calculate that, you have to remember A=(pi)(r)^2. If you do the math, you'll find that a .40 has about 25% more cross sectional area than a 9mm, and a .45 has about 27% more cross sectional area than a .40. That's why you want good expanding rounds, to make the area bigger. But with no expansion at all and equal penetration, a .40 destroys 25% more than a 9mm, and a .45 destroys 27% more than a .40.
All things being equal, the larger round a) destroys more tissue b) gives a better chance of hitting something that stops the fight. Of course, it usually adds more recoil that the shooter has to deal with, as well, and a hit with a 9mm is better than a miss with a .45. So basically, pick the largest bullet you can control.
With all of that said, the BEST thing you can do is place shots accurately. I've seen autopsy photos of a guy shot 47 times (yes, 47!) in the chest with various 9mm's. He was still fighting when the first 12 gauge slug hit him in the chest. He kept fighting until the second 12 gauge slug hit him, this time in the spine, turning him "off".
He was on nothing but adrenaline, and I suspect that if any of those 9mm rounds had hit his spine he would have stopped. Instead he was peppered with lung hits, possibly fatal, but not stopping him. Remember: It does no good killing someone if they live long enough to return the favor. What you want is to STOP it, NOW. Carry the biggest thing you can shoot accurately and quickly. Place shots well. Practice.
It isn't the caliber diameter that you compare, it's the area. To calculate that, you have to remember A=(pi)(r)^2. If you do the math, you'll find that a .40 has about 25% more cross sectional area than a 9mm, and a .45 has about 27% more cross sectional area than a .40. That's why you want good expanding rounds, to make the area bigger. But with no expansion at all and equal penetration, a .40 destroys 25% more than a 9mm, and a .45 destroys 27% more than a .40.
All things being equal, the larger round a) destroys more tissue b) gives a better chance of hitting something that stops the fight. Of course, it usually adds more recoil that the shooter has to deal with, as well, and a hit with a 9mm is better than a miss with a .45. So basically, pick the largest bullet you can control.
With all of that said, the BEST thing you can do is place shots accurately. I've seen autopsy photos of a guy shot 47 times (yes, 47!) in the chest with various 9mm's. He was still fighting when the first 12 gauge slug hit him in the chest. He kept fighting until the second 12 gauge slug hit him, this time in the spine, turning him "off".
He was on nothing but adrenaline, and I suspect that if any of those 9mm rounds had hit his spine he would have stopped. Instead he was peppered with lung hits, possibly fatal, but not stopping him. Remember: It does no good killing someone if they live long enough to return the favor. What you want is to STOP it, NOW. Carry the biggest thing you can shoot accurately and quickly. Place shots well. Practice.