Even a 30-06 is overkill. A .223 will kill a deer dead! With proper ammo and you hit where every hunter should hit the deer. I would think removing the rear 3/4 of the dear with some of these Kodiak killers would be counter productive.
I don’t like looking for deer so...
The 45-70, .444, .450, even .44 Mag blow thru the deer making a bigger hole & dumping more energy on the way thru.
Being a good Kodiak Killer does not necessarily make a caliber or cartridge a poor whitetail Killer.
I’ve had near 100% bang flop with an old plain vanilla .270 Winchester.
I believe my .260 Remington will Be just as efficient.