I have a 22-250 that I purchased for my wife. It is a Browning Abolt Medallion with a supposed twist rate of 1:14. I typically reload very light bullets for it and have heard that 55 grn bullets are my max, well she wants to do some deer hunting this year and I was debating upon load some 60 grn Nosler partitions up for it, and wanted a few opinions on the topic. Before anyone say this is unethical hunting, you should know that with 45 grn Hornady Xtp's she can shoot quarter sized 5 shot groups at 100 yards, so I have no doubt she can quickly drop a deer with the right bullet.