Who is supporting a single shot of any caliber? I dont care if I am shooting with my 22, 45, or 308... I am shooting until the threat is neutralized, the weapon runs dry, or I am unable to shoot it for whatever reason.
That last part is the key. The ineffectiveness of a 22 in self defense makes it much more likely that you will not stop the attack before the attacker gets to you or returns fire and the REASON you will be "unable to shoot" is because you're dead.
And again, the outcome of a defensive encounter is most often determined by the first one or two rounds fired.
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