I might be old school (definitely old age wise) but I always recommend a revolver for the ladies. That is unless she is going to go to the range regularly to practice. No worry with a revolver whether there is a round chambered or if the safety is on or off.
Having said that, my wife carries a semi auto but she can shoot it well.
For years my wife got the "little lady" treatment.
"Little lady, you need a revolver"
All she wanted was a semi-auto, but she has nerve damage in one finger and no hand strength and could never rack anything. Plus she always forgot how to do all of the manipulation. I would show her and go over everything at home just before the range. As soon as we got there she forgot EVERYTHING! Plus she is left handed and does everything backwards and upside down! FRUSTRATING!
Finally, I got her a Ruger LCR 38s. She is not a fan but never a problem using it. "Dummy free operation"
Hard to choose for someone with that much going on but had to be done.
I agreed with training and see what she likes and is confident with and there it is.
My wife still has her favorites and will not let go: Walther P22, Bersa thunder "CC" .380 She is very good with her 20g and AR-15.