Shoot’em in the face thenThere are a number of differences.
Big ones:
1. 5.7x28 is centerfire. Inherently more reliable than rimfire. This is the biggest one for me.
2. 5.7 defeats level 2 armor out of handgun, and depending on round selection, can defeat level 3.
2b. 22lr and 22 mag are stopped dead in their tracks by level 2 armor.
3. Generally and roughly speaking, 5.7 has over double the energy of 22 mag out of a handgun.