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Best Handgun Defensive Caliber for Old Arthritic Granny?

22 LR on top.
22 mag on bottom

Or a Shockwave in 20, or 410.
Those 410 round disks mixed with #4 would hurt
It has to be light and easy. Not for us, but her. It can't weigh anything, have no recoil and simple simple simple. Unfortunately means little stopping power. But that's what he's working with
 
A revolver -- a small frame revolver -- is the worst possible choice for a weak senior woman, because the double action trigger pull on those things are terrible!
Usually around 12 to 15 pounds.
The S&W easy 380 pistols are actually single action trigger mechanisms but with a long enough travel and enough weight to them that they don't feel like single action they feel like a striker fired safe action type trigger.
 
Look into this Walther. Bought one for my 70 year old wife w/ arthritic hands. She can easily rack the slide and control the recoil. Win / Win. PD 380
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Check out the G25 (Glock 19 sized). It’s a wonderfully soft shooter and very accurate.

Street price is about $500. I’ve never had a hiccup with mine.
 
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